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腺苷酸活化蛋白激酶：炎症调控新靶点

姚烽, 汲广岩, 张力^*

重庆医科大学 临床学院；病理生理学教研室，重庆 400016

摘要

腺苷酸活化蛋白激酶(AMP-activated protein kinase, AMPK)是参与调节糖、脂肪和蛋白质的代谢，维持细胞能量稳态的关键丝氨酸/苏氨酸蛋白激酶。新近研究表明：AMPK可通过磷酸化SIRT1、PGC-lα、p53和FoxO3a等下调核因子-κB的活性、抑制炎症相关基因的表达并减轻组织炎症损伤；此外，临床常用的降糖药二甲双胍也可通过激活AMPK而减轻炎症损伤。因而，AMPK将成为极具前景的抗炎药物开发新靶点。本文就AMPK的炎症调控效应及其分子机制作一综述。

关键词： 腺苷酸活化蛋白激酶; 炎症; 核因子-κB; 二甲双胍

分类号：R364.5；Q55

[AMPK: a novel target controlling inflammation.] [Article in Chinese]

YAO Feng, JI Guang-Yan, ZHANG Li^*

College of Clinical Medicine； Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China

Abstract

The AMP-activated protein kinase (AMPK) is a pivotal serine/threonine kinase participating in the regulation of glucose, lipid as well as protein metabolism and maintenance of energy homeostasis. Recent studies demonstrated that AMPK can also inhibit nuclear factor-κB, suppress the expression of inflammatory genes and attenuate inflammatory injury through phosphorylating its downstream targets including SIRT1, PGC-lα, p53 and FoxO3a. In addition, the widely used antidiabetic metformin also exerts its anti-inflammatory effects through activating AMPK. Therefore, AMPK is emerging as a promising novel target for the development of anti-inflammatory drugs. This review summarized the anti-inflammatory effects of AMPK and the underling molecular mechanisms.

Key words: AMP-activated protein kinase; inflammation; nuclear factor-κB; metformin

收稿日期：2011-11-05　　录用日期：2012-01-17

通讯作者：张力　　E-mail: zhangli@cqmu.edu.cn

引用本文：

姚烽, 汲广岩, 张力. 腺苷酸活化蛋白激酶：炎症调控新靶点[J]. 生理学报 2012; 64 (3): 341-345.

YAO Feng, JI Guang-Yan, ZHANG Li. [AMPK: a novel target controlling inflammation.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 341-345 (in Chinese with English abstract).