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慢性吗啡耐受大鼠脑内孤啡肽生成与释放增加

袁立, 韩宙, 张肇康, 韩济生

北京医科大学神经科学研究所.北京 100083；凤凰制药有限公司.美国,加州 94043

摘要

采用放射免疫分析法测定了慢性吗啡耐受过程中大鼠脑室灌流液、中脑导水管周围灰质(PAG)及杏仁核中孤啡肽(OFQ)免疫活性(ir)的动态变化。结果提示:长时间大剂量给予外源性吗啡可加速脑内OFQ的生成和释放,这可能是慢性吗啡耐受形成机制之一。

关键词： 孤啡肽; 慢性吗啡耐受; 放射免疫分析; 中脑导水管周围灰质; 杏仁核; 脑室灌流液

Increased release of orphanin FQ (OFQ) in brain of chronic morphine tolerant rats

Yuan Li, Han Zhou, Zhang Zhaokang, Han Jisheng

Neuroscience Research Institute,Beijing Medical University.Beijing 100083

Abstract

The changes in OFQ-immunoreactivity (OFQ-ir) content and release of cerebroventricular perfusate, periaqueductal gray (PAG) and amygadala of chronic morphine tolerant rats were measured with radioimmunoassay (RIA). The results suggested that in the later stage of chronic morphine treatment, large amount of OFQ was released from rat brain to antagonize the effect of opioids, which may play an important role in the development of morphine tolerance.

Key words: Orphanin FQ;Chronic morphine tolerance;Radioimmunoassay;Periaqueductal gray;Amygdala;Cerebroventricular perfusate

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引用本文：

袁立, 韩宙, 张肇康, 韩济生. 慢性吗啡耐受大鼠脑内孤啡肽生成与释放增加[J]. 生理学报 1999; 51 (4): .

Yuan Li, Han Zhou, Zhang Zhaokang, Han Jisheng. Increased release of orphanin FQ (OFQ) in brain of chronic morphine tolerant rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).