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红核在肌梭传入抑制伤害性反应中的作用

唐斌, 樊小力, 汪丛莹, 李强

西安医科大学生理学教研室.陕西,西安 710061

摘要

用玻璃微电极细胞外记录方法,观察了刺激红核对皮肤强电刺激诱发的大鼠脊髓背角广动力范围(wide dynamic range,WDR)神经元长潜伏期反应(C-反应)的作用,及红核对琥珀胆碱(succinylcholine,SCH)诱发的肌梭传入抑制WDR神经元C-反应效应的影响。结果提示,5-HT参与红核的痛下行抑制作用,在肌梭传入镇痛中红核起着一定的作用。

关键词： 红核; 肌梭; WDR神经元; 镇痛

Role of red nucleus in inhibiting nociceptive responses of rat spindle afferent

Tang Bin, Fan Xiaoli, Wang Congying, Li Qiang

Department of Physiology,Xi^an Medical University.Xi^an 710061,Shaanxi

Abstract

Using extracellular recording techniques, the effect of excitation of red nucleus (RN) on C-responses of wide dynamic range (WDR) neurons and the roles of RN in the inhibitory effect of spindle afferent activated by succinycholine (SCH) on C-responses of WDR neurons were studied. Stimulation of RN caused a significant reduction of nociceptive responses of WDR neurons, which was significantly attenuated by intravenous cyproheptadine and contralateral lesion of RN.

Key words: Red nucleus;Wide dynamic range neurons;Muscle spindle;Analgesia

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引用本文：

唐斌, 樊小力, 汪丛莹, 李强. 红核在肌梭传入抑制伤害性反应中的作用[J]. 生理学报 1999; 51 (4): .

Tang Bin, Fan Xiaoli, Wang Congying, Li Qiang. Role of red nucleus in inhibiting nociceptive responses of rat spindle afferent. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).