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刺激大鼠离断背根外周端对相邻背根电活动的影响

张勇, 邓云平, 关新民

同济医科大学神经生物学教研室.湖北,武汉 430030

摘要

在切断大鼠左侧L2、L3背根后,观察电刺激(刺激参数为0.8-1.2mA,100Hz,0.5ms,总时程2s)L2背根外周端对L3背根放电活动的影响。结果表明:连续多次刺激L2背根可使L3背根平均放电频率(MDF)逐步增加,增加量与刺激次数呈明显直线正相关。各次刺激后的时程分析表明,这种增频作用具有明显的累积效应和后效应,并与刺激前L3背根的活动状态密切相关,刺激前放电活动较强者其增频作用更明显。

关键词： 背根; 感觉神经末梢; 信息传递; 大鼠

Effect of stimulating the peripheral endings of transected dorsal root on discharges of neighbouring dorsal root in rats

Zhang Yong, Deng Yunping, Guan Xinmin

Department of Neurobiology,Tongji Medical University.Wuhan 430030,Hubei

Abstract

The dorsal roots (DR) of L2-L3 segments on the left side in anesthetized rats (n=28) were exposed and transected. After stimulating the peripheral endings of L2 DR with a train of square waves (0.8-1.2mA, 100 Hz, 0.5 ms) for 2 s, the discharges at the distal end of transected L3 DR were recorded for 120 s. We found that the mean discharge frequency (MDF) of L3 DR was gradually increased with L2 DR stimulation. Time course analysis showed that the increase in MDF was linearly correlative to the number of stimuli, as well as to the levels of spontaneous discharge of L3 DR.

Key words: Dorsal root;Sensory nerve endings;Information transmission;Rat

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引用本文：

张勇, 邓云平, 关新民. 刺激大鼠离断背根外周端对相邻背根电活动的影响[J]. 生理学报 1999; 51 (4): .

Zhang Yong, Deng Yunping, Guan Xinmin. Effect of stimulating the peripheral endings of transected dorsal root on discharges of neighbouring dorsal root in rats. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).