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海马内NA能神经损毁对抗急性低氧诱发皮质酮分泌

朱晓蔓, 朱子涛, 温传俊, 周予谦

南京铁道医学院生理教研室.江苏,南京 210009；南京铁道医学院药理教研室.江苏,南京 210009

摘要

吸入10.4% O_(2) 30min后血浆皮质酮水平显著升高,6-羟多巴胺(6-OHDA)注入腹侧海马致使海马内去甲肾上腺素(NA)含量降低(-38.5%);血浆皮质酮水平也较未损毁组为低(-33.2%)。吸入10.4% O_(2)后,皮质酮对低氧刺激的反应性升高现象消失。

关键词： 低氧; 皮质酮; 海马; 6-羟多巴胺

Destruction of NA innervation in the rat hippocampus resists the hypoxia-induced corticosterone secretion

Zhu Xiaoman, Zhu Zitao, Wen Chuanjun, Zhou Yuqian

Department of Physiology,Nanjing Railway Medical College.Nanjing 210009,Jiangsu

Abstract

The plasma CS response to inhalation of 10.4% O_(2) (30 min) was increased markedly; while the plasma CS level and the noradrenaline (NA) contents in hippocampus were decreased (-33.2% and -38.5%, respectively) 2 weeks after microinfusion of 6-OHDA (8 #mu#g/2 #mu#l) into VHIP; however, the CS response to acute hypoxia was unaffected by 6-OHDA lesion of VHIP.

Key words: Hypoxia;Corticosterone;Hippocampus;6-hydroxydopamine (6-OHDA)

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引用本文：

朱晓蔓, 朱子涛, 温传俊, 周予谦. 海马内NA能神经损毁对抗急性低氧诱发皮质酮分泌[J]. 生理学报 1999; 51 (3): .

Zhu Xiaoman, Zhu Zitao, Wen Chuanjun, Zhou Yuqian. Destruction of NA innervation in the rat hippocampus resists the hypoxia-induced corticosterone secretion. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).