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微透析测试刺激皮肤和肌肉神经引起的天门冬氨酸和谷氨酸在脊髓的释放

宋学军, 舒友生, 尹萍波, 赵志奇

中科院上海脑研究所.上海 200031；中科院上海生理研究所神经生物学开放实验室.上海 200031

摘要

应用微透析技术,测量刺激皮肤和肌肉神经引起的天门冬氨酸(Asp)和谷氨酸(Glu)的脊髓背角的释放。提示,皮肤伤害性传入主要引起Asp的释放增加,而肌肉的伤害性传入则主要引起Glu的释放增加,它们分别主要作用于NMDA和非NMDA受体而介导不同的痛传入信息。

关键词： 天门冬氨酸; 谷氨酸; 微透析; 脊髓伤害性感受

Detection of release of aspartate and glutamate in cat spinal dorsal horn following noxious stimulation of cutaneous and muscular afferent fibers using microdialysis

Song Xuejun, Shu Yousheng, Yin Pingbo, Zhao Zhiqi

Shanghai Brain Research Institute,Chinese Academy of Sciences.Shanghai 200031；China

Abstract

Asp and Glu were increased respectively by (323±55)% and (169±16)% following stimulation of cutaneous nerve, but by (150±16)% and (218±42)% respectively following stimulation of muscular nerve. Asp increase was approximately three times higher than that of Glu following cutaneous nerve-stimulation (P<0.01), while Glu increase was approximately twice as high as that of Asp following muscular nerve-stimulation (P<0.05).

Key words: Glutamate;Aspartate;Microdialysis;Spinal nociception

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引用本文：

宋学军, 舒友生, 尹萍波, 赵志奇. 微透析测试刺激皮肤和肌肉神经引起的天门冬氨酸和谷氨酸在脊髓的释放[J]. 生理学报 1999; 51 (3): .

Song Xuejun, Shu Yousheng, Yin Pingbo, Zhao Zhiqi. Detection of release of aspartate and glutamate in cat spinal dorsal horn following noxious stimulation of cutaneous and muscular afferent fibers using microdialysis. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).