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内皮素通过最后区易化大鼠延髓腹外侧头端区神经元活动

李德培, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

循环中的ET-1可与最后区(AP)神经元上的ET_(A)受体相结合而引起兴奋,转而经AP的传出投射再易化延髓腹外侧头端区(RVLM)区神经元活动。

关键词： 内皮素; 延髓腹外侧头端区; 最后区; 自发放电单位; BQ-123

Intracarotid injection of endothelin-1 facilitates the activity of rostral ventrolateral medullary neurons via area postrema in rats

Li Depei, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Intracarotid administration of ET-1 (0.3mmol/kg) increased the discharge firing rate from 17.8±1.5 to 20.9±1.4 spikes/s (P<0.01) in 30 out of 36 RVLM neurons, while blood pressure and heart rate had no significant change. BQ-123 (0.67nmol/kg), a selective ET_(A) blocker, completely blocked the facilitatory effects of ET-1 in 11 out of 14 units. In 10 out of 11 units, glibenclamide (3.3nmol/kg), a blocker of ATP-sensitive potassium channel, had no effect on the action of ET-1. After ablation of area postrema (AP), the facilitatory action of intracarotid administration of ET-1 on 19 units of RVLM was abolished, while in 7 units of sham ablation animals the response of neurons to ET-1 remained unchanged.

Key words: Endothelin;Rostral ventrolateral medulla (RVLM);Area postrema;Spontaneous discharge units;BQ-123

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引用本文：

李德培, 何瑞荣. 内皮素通过最后区易化大鼠延髓腹外侧头端区神经元活动[J]. 生理学报 1999; 51 (3): .

Li Depei, He Ruirong. Intracarotid injection of endothelin-1 facilitates the activity of rostral ventrolateral medullary neurons via area postrema in rats. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).