过刊浏览

胍基丁胺对大鼠血流动力学的影响及其细胞机制

李晓滔, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

胍基丁胺(AGM)对麻醉大鼠的降压机制,在于显著抑制心肌收缩性而使心输出量降低,以及舒张外周血管致使总外周阻力下降;此效应似主要由IR和/或#alpha#_(2)-AR所介导。

关键词： 胍基丁胺; 血流动力学; 咪唑啉受体; α_(2)受体

Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats

Li Xiaotao, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results indicate that the hypotensive effect induced by iv agmatine may be attributed to the decrease in cardiac output resulting from depression of myocardial contractlity, as well as to the reduction in total peripheral resistance resulting from vasodilatation. These effects of agmatine may be mediated by imidazoline receptor and/or #alpha#_(2)-AR.

Key words: Agmatine;Hemodynamics;Imidazoline receptor;#alpha#_(2)-adrenoceptor

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

李晓滔, 何瑞荣. 胍基丁胺对大鼠血流动力学的影响及其细胞机制[J]. 生理学报 1999; 51 (2): .

Li Xiaotao, He Ruirong. Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).