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培养大鼠主动脉血管平滑肌细胞产生巨噬细胞集落刺激因子及其受体的表达

朱鼎良, Gogusev J, Marche P

上海第二医科大学附属瑞金医院.上海 200025；法国国家健康医学研究院,90研究单位.巴黎 75015

摘要

首次报道了培养大鼠主动脉血管平滑肌细胞(VSMCs)能合成并分泌具有生物活性的巨噬细胞集落刺激因子(MCSF),而且该细胞存在MCSF受体。结果提示,MCSF可能以自分泌或旁分泌方式调节VSMCs功能,为研究MCSF对于VSMCs的增殖作用及其机制提供合适的细胞模型。

关键词： 血管平滑肌细胞; 巨噬细胞集落刺激因子; 巨噬细胞集落刺激因子受体

Macrophage colony-stimulating factor production and c-fms expression in cultured rat aortic vascular smooth muscle cells

Zhu Dingliang, Gogusev J, Marche P

Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Second Medical University.Shanghai 200025；France

Abstract

The presence of mRNAs for MCSF and c-fms (which encoded MCSF receptor) was determined by Northern blot analysis. Their expressions were detectable in quiescent VSMCs and markedly increased after addition of serum. These data demonstrated for the first time the production of MCSF and the presence of MCSF receptor in cultured rat VSMCs. It is suggested that MCSF might modulate VSMCs functions via both autocrine and paracrine mechanisms. Rat VSMCs appear to be a suitable cell model for studying the cell proliferation effect of MCSF.

Key words: Vascular smooth muscle cell;Macrophage colonystimulating factor;Macrophage colonystimulating factor receptor

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引用本文：

朱鼎良, Gogusev J, Marche P. 培养大鼠主动脉血管平滑肌细胞产生巨噬细胞集落刺激因子及其受体的表达[J]. 生理学报 1999; 51 (2): .

Zhu Dingliang, Gogusev J, Marche P. Macrophage colony-stimulating factor production and c-fms expression in cultured rat aortic vascular smooth muscle cells. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).