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间歇性低氧对大鼠心室肌细胞短暂外向电流的影响

周军, 田鸣, 张翼, 周兆年

中科院上海生理研究所.上海 200031；徐州医学院麻醉生理研究所.江苏,徐州 221002

摘要

利用全细胞膜片箝方法研究间歇性低氧后左、右心室肌细胞短暂外向电流(Ito)的变化,以探讨间歇性低氧增强心肌电稳定性的离子机制。Ito密度的改变可反映心室在低氧早期阶段的不同动力学反应。失活动力学改变参与间歇性低氧心脏保护机制。

关键词： 间歇性低氧 短暂外向电流; 膜片箝技术; 适应; 心脏

Effects of intermittent hypoxia on transient outward current in rat ventricular myocytes

Zhou Jun, Tian Ming, Zhang Yi, Zhou Zhaonian

Shanghai Institute of Physiology,Chinese Academy of Sciences.Shanghai 200031；China

Abstract

To explore the ionic basis of the strengthening effect of intermittent hypoxic adaptation (IHA) on the electric stability of heart, the effects of intermittent hypoxia on the transient outward current (Ito) in rat ventricular myocytes were investigated hy using whole-cell patch-clamp recording techniques. It is speculated that the change in the current density of Ito may be responsible for the different hemodynamic responses of the ventricles to the early stage of hypoxia. The alteration in inactivation may participate in the cardioprotective effect of IHA.

Key words: Intermittent hypoxia;Transient outward current;Patchclamp technique;Adaptation heart

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引用本文：

周军, 田鸣, 张翼, 周兆年. 间歇性低氧对大鼠心室肌细胞短暂外向电流的影响[J]. 生理学报 1999; 51 (2): .

Zhou Jun, Tian Ming, Zhang Yi, Zhou Zhaonian. Effects of intermittent hypoxia on transient outward current in rat ventricular myocytes. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).