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提高胞外钾引起的蛙骨骼肌咖啡因挛缩增强

陈克樱, 朱培闳

中科院上海生理研究所细胞信号转导组.上海 200031

摘要

用蛙胫前肌小束为材料,研究了提高胞外钾[K~(+)]_(0)对咖啡因挛缩的作用。[K~(+)]_(0)从2mmol/L提高到10或25mmol/L,由3mmol/L咖啡因引起的挛缩明显增强。结果提示,至少在蛙骨骼肌,高钾引起的咖啡因挛缩增强主要是由胞浆自由钙升高引起的。

关键词： 骨骼肌; 钙释放通道; 咖啡因; 高钾; 挛缩

Potentiation of caffeine-induced contracture by raising extracellular potassium in frog skeletal muscle

Chen Keying, Zhu Peihong

Unit of Cell Signal Transduction,Shanghai Institute of Physiology,Chinese Academy of Sciences.Shanghai 200031

Abstract

The effect of raising extracellular potassium ([K~(+)]_(0)) on caffeine contracture was investigated, using small bundles dissected from frog anterior tibialis muscle. It is suggested that, at least in frog skeletal muscle, the high [K~(+)]_(0) induced potentiation of caffeine contracture is mainly due to an increase of myoplasmic free calcium.

Key words: Skeletal muscle;Ryanodine receptor;Caffeine;High potassium;Contracture

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引用本文：

陈克樱, 朱培闳. 提高胞外钾引起的蛙骨骼肌咖啡因挛缩增强[J]. 生理学报 1999; 51 (2): .

Chen Keying, Zhu Peihong. Potentiation of caffeine-induced contracture by raising extracellular potassium in frog skeletal muscle. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).