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组胺对大鼠小脑皮层浦肯野细胞的兴奋作用

田乐, 温云卿, 李红召, 熊化保, 王建军

南京大学生物科学与技术系.江苏,南京 210093

摘要

在离体大鼠小脑脑片上观察了组胺对小脑皮层第X小叶浦肯野细胞的作用。组胺(3-100#mu#mol/L)主要引起浦肯野细胞的兴奋反应(94.4%,51/54),在少数细胞上也观察到组胺所引起的放电抑制现象(5.6%,3/54)。组胺可能主要通过H_(2)受体的介导对浦肯野细胞起兴奋性调节作用,下丘脑-小脑组胺能神经通路可能参与了小脑的某些躯体的和非躯体的功能调节。

关键词： 组胺; 小脑浦肯野细胞; 下丘脑; 小脑组胺能纤维; 小脑脑片

The excitatory effects of histamine on cerebellar cortical Purkinje cells in the rat

Tian Le, Wen Yunqing, Li Hongzhao, Xiong Huabao, Wang Jianjun

Department of Biological Science and Technology,Nanjing University.Nanjing 210093,Jiangsu

Abstract

The effects of histamine on Purkinje cells (PCs) in lobule X of cerebellar cortex were investigated in rat cerebellar slices. Histamine elicited PCs^ responses predominately excitatory (94.4%,51/54), only few inhibitory (5.6%,3/54). Results suggest that histamine exerts an excitatory effect on the PCs via H_(2) receptors. Presumably, hypothalamo-cerebellar histaminergic fibers participate in the regulation of somatic and non-somatic functions of the cerebellum.

Key words: Histamine;Cerebellar Purkinje cell;Hypothalamocerebellar histaminergic fibers;Cerebellar slice;

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引用本文：

田乐, 温云卿, 李红召, 熊化保, 王建军. 组胺对大鼠小脑皮层浦肯野细胞的兴奋作用[J]. 生理学报 1999; 51 (2): .

Tian Le, Wen Yunqing, Li Hongzhao, Xiong Huabao, Wang Jianjun. The excitatory effects of histamine on cerebellar cortical Purkinje cells in the rat. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).