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视皮层LTP维持阶段的突触形态计量学研究

陈玉翠, 韩太真, 沈建新, 乔健天

汕头大学医学院生理教研室.广东,汕头 515031；山西医科大学生理教研室.山西,太原 030001

摘要

实验使用18-20d的幼年大鼠视皮层脑片标本,在LTP出现后3h取局部微脑片固定进行LTP维持阶段超微结构的研究。分别与孵育相同时间而未予任何刺激的脑片和仅给予测试刺激的脑片作比较。结果提示:活性区面密度的增加及突触界面曲率的增大可能是LTP维持的形态学基础。穿孔性突触的形成与LTP的维持密切相关。

关键词： LTP; 视皮层脑片; 突触间隙; 突触后致密物质; 突触界面曲率; 棘突触; 穿孔性突触

A quantitative study on the synaptic ultrastructural alterations in visual cortex in the maintenance of LTP

Chen Yucui, Han Taizhen, Shen Jianxin, Qiao Jiantian

Department of Physiology,Medical College,Shantou University.Shantou 515031,Guangdong；China

Abstract

The ultrastructure of synapses three hours after formation of long-term potentiation (LTP) was examined in the local microslices of visual cortical brain slices of 18-20d rats. Slices without potentiating stimulation which were similarly incubated served as controls.

Key words: long term potentiation (LTP);Visual cortical brain slice;Synaptic cleft;Postsynaptic densities(PSD);The curvature of the synaptic interface spine synapse;Perforated synapse;

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引用本文：

陈玉翠, 韩太真, 沈建新, 乔健天. 视皮层LTP维持阶段的突触形态计量学研究[J]. 生理学报 1999; 51 (1): 73-79.

Chen Yucui, Han Taizhen, Shen Jianxin, Qiao Jiantian. A quantitative study on the synaptic ultrastructural alterations in visual cortex in the maintenance of LTP. Acta Physiol Sin 1999; 51 (1): 73-79 (in Chinese with English abstract).