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内皮素-1对培养新生大鼠心肌细胞原癌基因c-fos表达的诱导

吴滨, 王庭槐, 朱小南, 潘敬运

中山医科大学生理教研室.广东,广州 510089

摘要

ET-1可显著诱导c-fos的表达,并呈剂量依赖性反应和被ET_(A)的特异性受体拮抗剂BQ123所阻断;蛋白激酶C(PKC)激动剂PMA可诱导c-fos表达,而PKC抑制剂Staurosporine则可阻断ET-1诱导的c-fos表达;钙通道阻断剂硝苯吡啶预处理心肌细胞对ET-1诱导的心肌细胞的c-fos表达无明显的作用。

关键词： 内皮素-1; 心肌细胞; c-fos

ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells

Wu Bin, Wang Tinghuai, Zhu Xiaonan, Pan Jingyun

Department of Physiology,Sun Yat-sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

In the present study, the effect of endothelin-1 (ET-1) on the expression of protooncogene c-fos in cultured neonatal rat myocardial cells was investigated. The results suggest that in cultured neonatal cardiomyocytes, ET-1 induced c-fos gene expression is mediated by ET_(A) receptor with the participation of protein kinase C, while the voltage-dependent L-type Ca~(2+) channel is not involved.

Key words: Endothelin-1;c-fos;Cardiomyocyte

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引用本文：

吴滨, 王庭槐, 朱小南, 潘敬运. 内皮素-1对培养新生大鼠心肌细胞原癌基因c-fos表达的诱导[J]. 生理学报 1999; 51 (1): 19-24.

Wu Bin, Wang Tinghuai, Zhu Xiaonan, Pan Jingyun. ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells. Acta Physiol Sin 1999; 51 (1): 19-24 (in Chinese with English abstract).