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阿片受体介导大鼠海马内脑啡肽对细胞免疫功能的调节

高娜, 王阿敬, 杨渝珍, 胡谋先, 谢虹

首都医科大学生理教研室.北京 100054；同济医科大学实验医学研究中心.湖北,武汉 430030

摘要

以刀豆蛋白A(Con A)刺激的脾淋巴细胞增殖活性及自然杀伤细胞(NK cell)活性为细胞免疫功能检测指标,观察了阿片受体阻断剂纳洛酮对大鼠海马内微量注射甲硫脑啡肽所致的免疫功能增强作用的影响。结果提示,海马内脑啡肽对免疫功能的增强作用是通过阿片受体介导的。

关键词： 神经免疫调节 ; 海马; 脑啡肽; 阿片受体

Opioid receptor mediated modulation of intrahippocampal enkephalin induced cellular immune function

Gao Na, Wang Ajing, Yang Yuzhen, Hu Mouxian, Xie Hong

Department of Physiology,Capital University of Medical Sciences.Beijing 100054；China

Abstract

In the present work, the effect of intrahippocampal microinjection of opioid receptor antagonist naloxone on the enhancement of cellular immune responses induced by enkephalin was studied in rat. The results suggest that the enhancement of cellular immune responses induced by enkephalin was mediated by opioid receptors in hippocampus.

Key words: Neuroimmunomodulation;Hippocampus;Enkephalin;Opioid receptor

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引用本文：

高娜, 王阿敬, 杨渝珍, 胡谋先, 谢虹. 阿片受体介导大鼠海马内脑啡肽对细胞免疫功能的调节[J]. 生理学报 1999; 51 (1): 106-110.

Gao Na, Wang Ajing, Yang Yuzhen, Hu Mouxian, Xie Hong. Opioid receptor mediated modulation of intrahippocampal enkephalin induced cellular immune function. Acta Physiol Sin 1999; 51 (1): 106-110 (in Chinese with English abstract).