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尾核阿片#mu#受体参与电针及皮层SmI区对束旁核伤害性反应的抑制

吴国冀, 陈正秋

中国中医研究院针灸研究所.北京 100700

摘要

用尾核(Cd)头部化学毁损及微量注射阿片受体拮抗剂的方法,观察到Cd毁损前电针及兴奋皮层均可抑制Pf的伤害性反应,而毁损后这种抑制效应消失;注射钠洛酮或阿片#mu#受体拮抗剂#beta#-FNA后,电针及兴奋皮层SmI区对Pf伤害性反应的抑制作用被取消,而分别注射#delta#和#kappa#受体拮抗剂ICI174,864和nor-BNI则不产生影响.

关键词： 尾核; 针刺镇痛; 大脑皮层; 束旁核; 阿片肽

Opioid #mu# receptors in caudate nucleus contribute to electroacupuncture and SmI generating inhibition on nociceptive responses of Pf neurons

Wu Guoji, Chen Zhengqiu

Institute of Acupuncture,China Academy of TCM.Beijing 100700

Abstract

The present experiments aimed to investigate whether the caudate nucleus (Cd) was involved in cortical sensorimotor area I (SmI) generating descending modulation of the parafascicular nucleus (Pf) in acupuncture analgesia (AA), and what type of opiate receptors in Cd were involved.

Key words: Caudate nucleus;Acupuncture analgesia;Cerebral cortex;Parafascicular nucleus;Opiate

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引用本文：

吴国冀, 陈正秋. 尾核阿片#mu#受体参与电针及皮层SmI区对束旁核伤害性反应的抑制[J]. 生理学报 1999; 51 (1): 49-54.

Wu Guoji, Chen Zhengqiu. Opioid #mu# receptors in caudate nucleus contribute to electroacupuncture and SmI generating inhibition on nociceptive responses of Pf neurons. Acta Physiol Sin 1999; 51 (1): 49-54 (in Chinese with English abstract).