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脑内血管紧张素II系统在穹窿下器升压反应中的应用

常彦忠, 顾蕴辉

北京医科大学生理系.北京 100083

摘要

用氨基甲酸乙脂麻醉、箭毒制动、人工呼吸的大鼠观察到:穹窿下器(SFO)、室旁核(NPV)或NPV的投射区:延髓头端腹外侧区(RVLM)、导水管周围灰质(PAG)、蓝斑(LC)内注入血管紧张素II(AII)均引起升压反应。SFO内的AII能神经元通过NPV内AII能神经元,不仅可直接作用于RVLM引起升压反应,而且还可间接通过PAG作用于RVLM起升压作用,但LC不参与SFO升压反应。

关键词： 血管紧张素Ⅱ; 升压反应; 穹窿下器; 室旁核; 导水管周围灰质; 蓝斑

Role of brain angiotensin II system in subfornical organ-pressor responses

Chang Yanzhong, Gu Yunhui

Department of Physiology,Beijing Medical University.Beijing 100083

Abstract

The authors studied the role of brain angiotensin II in subfornical organ-pressor responses using urethane-anesthetized, tubocurarine-immobilized rats, and the present work obtained the following finding: angiotensin II (AII) induced pressor responses by injection into several brain regions: either subfornical organ (SFO), nucleus paraventricularis (NPV) or its projection areas, including rostral ventrolateral medulla (RVLM), periaqueductal gray matter (PAG) and locus coeruleus (LC).

Key words: Angiotensin Ⅱ;Pressor response;Subfornical organ;Nucleus paraventricularis;Periaqueductal gray matter;Locus coeruleus

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引用本文：

常彦忠, 顾蕴辉. 脑内血管紧张素II系统在穹窿下器升压反应中的应用[J]. 生理学报 1999; 51 (1): 38-44.

Chang Yanzhong, Gu Yunhui. Role of brain angiotensin II system in subfornical organ-pressor responses. Acta Physiol Sin 1999; 51 (1): 38-44 (in Chinese with English abstract).