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家兔单侧、双侧Botzinger复合体内微量注射甘氨酸及士的宁对膈神经放电的影响

吕明, 李勤, 宋刚, 张衡, 刘磊

山东医科大学基础医学院生理学教研室.山东,济南 250012

摘要

实验在34只氨基甲酸乙酯麻醉、断双侧颈迷走神经、肌松、人工通气的家兔上进行。单侧和双侧Botzinger复合体(Bot.C)内微量注射抑制性神经递质甘氨酸及其受体阻断剂士的宁,观察膈神经放电的变化。结果提示:Bot.C在呼气相的形成和维持中起关键作用。

关键词： Botzubger复合体; 膈神经放电; 微量注射; 甘氨酸; 士的宁

Effects of glycine and strychnine microinjected into unilateral and bilateral Botzinger complex on phrenic nerve discharges in rabbits

Lu Ming, Li Qin, Song Gang, Zhang Heng, Liu Lei

Department of Physiology,Shandong Medical University.Jinan 250012,Shandong

Abstract

The effects of microinjection of glycine and strychnine into unilateral and bilateral Botzinger complex (Bot.C) on phrenic nerve discharges were observed in 34 urethane anaesthetized, vagotomized, paralyzed and artificially ventilated rabbits. The results suggest that the Bo.C plays a crucial role in initiating and sustaining expiration.

Key words: Botzinger complex;Phrenic nerve discharges;Microinjection;Glycine;Strychnine

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引用本文：

吕明, 李勤, 宋刚, 张衡, 刘磊. 家兔单侧、双侧Botzinger复合体内微量注射甘氨酸及士的宁对膈神经放电的影响[J]. 生理学报 1998; 50 (6): .

Lu Ming, Li Qin, Song Gang, Zhang Heng, Liu Lei. Effects of glycine and strychnine microinjected into unilateral and bilateral Botzinger complex on phrenic nerve discharges in rabbits. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).