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一氧化氮及去内皮对颈动脉窦压力感受器活动的影响

夏林英, 钮伟真, 沈靖, 刘北英

首都医科大学心血管研究室.北京 100054

摘要

研究了外源性一氧化氮(NO)及内皮对家兔离体CS压力感受器活动(BRA)的影响,并进一步探讨其作用机制。结果证明:外源性NO对CS-BRA有明显的兴奋作用,这种作用有赖 于内皮的完整性,其作用不是由cGMP介导的。

关键词： 压力感受器; 一氧化氮; 内皮; 颈动脉窦; 家兔

Effects of NO and endothelium on carotid baroreceptor activity

Xia Linying, Niu Weizhen, Shen Jing, Liu Beiying

Department of Cardiovascular Physiology,Capital University of Medical Sciences.Beijing 100054

Abstract

The present study was undertaken to examine the effects of endothelium and exogenous NO on the baroreceptor discharge of the carotid sinus. The baroreceptor activity (BRA) was recorded from the rabit carotid sinus-sinus nerve (CS-CSN) preparation using a chamber for superfusing and perfusing the tissue. Results indicate that stimulation of BRA by exogenous NO may be mediated by the endothelium, but cGMP dose not seem to be involved.

Key words: Baroreceptor;Nitric oxide;Endothelium;Carotid sinus;Rabbit

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引用本文：

夏林英, 钮伟真, 沈靖, 刘北英. 一氧化氮及去内皮对颈动脉窦压力感受器活动的影响[J]. 生理学报 1998; 50 (6): .

Xia Linying, Niu Weizhen, Shen Jing, Liu Beiying. Effects of NO and endothelium on carotid baroreceptor activity. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).