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NO对家兔Oddi括约肌肌电活动和血压的影响

张敏, 丁春华, 张连巍, 杨思禹

河北医科大学病理生理学教研室.河北,石家庄 050017；河北医科大学门诊部.河北,石家庄 050017

摘要

应用32只家兔观察一氧化氮(NO)对Oddi括约肌(SO)肌电和血压的影响。静脉注射NO合酶抑制剂N~(G)-硝基-L-精氨酸(L-NNA),可见SO肌电振幅增大和血压升高,L-NNA所致的肌电活动增强可被L-精氨酸(L-arg)反转,而L-NNA所致的血压升高却未因L-arg的应用而下降。静脉注射能直接释放NO的药物硝普钠(SNP),引起SO肌电振幅、频率以及血压明显降低,而且存在明显的量效关系。

关键词： 一氧化氮; Oddi括约肌; 肌电; 血压; 家兔

Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei；China

Abstract

Thirty-two rabbits were used to investigate the effect of nitric oxide (NO) on the myoelectric activity of the sphincter of Oddi (SO) and arterial blood pressure. Intravenous infusion of N~(G)-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthase (NOS), caused increased in SO phasic wave amplitude and arterial blood pressure. The increase in SO phasic wave amplitude by infusion of L-NNA was reversed by L-arginine, but arterial blood pressure remained at a high level. It was observed that SO phasic wave amplitude, frequency and arterial blood pressure were significantly decrease by intravenously infusion of sodium nitroprusside (SNP), a substance producing.

Key words: Sphincter of Oddi;Myoelectric activity;Nitric oxide;Arterial blood pressure;Rabbit

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引用本文：

张敏, 丁春华, 张连巍, 杨思禹. NO对家兔Oddi括约肌肌电活动和血压的影响[J]. 生理学报 1998; 50 (6): .

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu. Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).