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基底外侧杏仁核对睡眠-觉醒的调节作用

朱国庆, 钟明奎, 张景行, 赵乐章, 柯道平, 王敏, 施蕾

安徽医科大学生理教研室.安徽,合肥 230032；安徽中医学院生理教研室.安徽,合肥 230032

摘要

采用多道睡眠描述方法,观察了基底外侧杏仁核(BLN)在睡眠-觉醒调节中的作用。结果发现,BLN是调节睡眠-觉醒的重要核团,损毁BLN可引起慢波睡眠增多,NO可通过兴奋BLN中神经元胞体而发挥促进觉醒和抑制慢收波睡眠效应。

关键词： 杏仁核; 红藻氨酸; 一氧化氮; 睡眠; 觉醒

Role of basolateral amygdaloid nuclei in sleep and wakeful state regulation

Zhu Guoqing, Zhong Mingkui, Zhang Jingxing, Zhao Lezhang, Ke Daoping, Wang Min, Shi Lei

Department of Physiology,Anhui Medical University.Hefei 230032,Anhui；China

Abstract

The role of basolateral amygdaloid nuclei (BLN) in sleep and wakeful state (W) was investigated with polysomnography. Electrical lesion of bilateral BLN increased show wave sleep (SWS) and paradoxical sleep (PS), but decreased W. Bilateral injection of kainic acid (KA), which selectively destroyed the soma of neurons, resulted in biphasic effects. At d 1 after KA, insomnia occurred. At d 4, SWS increased while W decreased, but PS did not change. Unilateral injection of NO donor sodium nitroferricyanide (SNP) caused an enhancement of W and a decrease of SWS. Injection of nitric oxide synthase inhibitor N-nitro-L-arginine (L-NNA) led to opposite effects. L-arginine, a precursor of NO, had no direct effect on sleep and W, but blocked the effects of L-NNA.

Key words: Amygdaloid complex;Kainic acid;Nitric oxide;Sleep;Wakeful state

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引用本文：

朱国庆, 钟明奎, 张景行, 赵乐章, 柯道平, 王敏, 施蕾. 基底外侧杏仁核对睡眠-觉醒的调节作用[J]. 生理学报 1998; 50 (6): .

Zhu Guoqing, Zhong Mingkui, Zhang Jingxing, Zhao Lezhang, Ke Daoping, Wang Min, Shi Lei. Role of basolateral amygdaloid nuclei in sleep and wakeful state regulation. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).