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糖皮质激素快速抑制牛蛙椎旁神经节B细胞快兴奋性突触后电位

马蓓, 易必达, 邢宝仁

第二军医大学生理教研室.上海 200433；贵阳医学院生理教研室.贵州,贵阳 550004

摘要

用单个方波电刺激牛蛙离体椎旁神经节节前纤维,细胞内记录节后B细胞快兴奋性突触后电位(f-EPSP),观察糖皮质激素(GC)对B细胞f-EPSP的快速抑制作用。结果发现,GC灌流3min,B细胞f-EPSP的幅值减小,撤除GC后,EPSP的幅值恢复到对照水平,作用具有剂量依赖性。糖皮质激素胞内受体阻断剂RU38486能阻断GC的快速抑制作用。

关键词： 糖皮质激素; 椎旁神经节; 兴奋性突触后电位; 快速作用

Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia

Ma Bei, Yi Bida, Xing Baoren

Department of Physiology,Second Military Medical University.Shanghai 200433；China

Abstract

In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione.

Key words: Glucocorticoid;Paravertebral ganglia;Excitatory postsynaptic potential;Rapid effect

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引用本文：

马蓓, 易必达, 邢宝仁. 糖皮质激素快速抑制牛蛙椎旁神经节B细胞快兴奋性突触后电位[J]. 生理学报 1998; 50 (6): .

Ma Bei, Yi Bida, Xing Baoren. Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).