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100Hz电针耐受时大鼠脑和脊髓#kappa#受体结合特性的改变

董艺娜, 毛慕华, 毛晓民, 韩济生

北京医科大学神经科学研究所.北京 100083；江西井冈山医学高等专科学校生理教研室.江西,吉安 343000

摘要

该文采用放射配体结合实验研究了100Hz电针耐受发生发展过程中大鼠脑和脊髓#kappa#受体结合特性的变化。大鼠每天给予100Hz电针1次(30min),连续7d。分别在电针的第1、3、5、7天取不同脑区进行观察。结果表明,每天给予100Hz电针连续7d,引起脑内特别是中脑和纹状体中#kappa#受体数目显著下调,这种变化是否参与电针耐受的形成机制值得进一步研究。

关键词： 电针; 镇痛; 耐受; k-阿片受体

Changes in the binding characteristics of central #kappa#-opioid receptor during the development of 100Hz electroacupuncture (EA) tolerance in rats

Dong Yina, Mao Muhua, Mao Xiaomin, Han Jisheng

Neuroscience Research Institute,Beijing Medical University.Beijing 100083；China

Abstract

The effect of repetitive 100Hz EA stimulation on the characteristics of binding of #kappa# opioid receptors in discrete brain regions and the spinal cord of rats was investigated by radioligand binding assay. 100Hz EA was administered once a day (30min) for 7d. Changes in B_(max) and Kd of #kappa# opioid receptors of 4 discrete brain regions (cortex, midbrain, pons-medulla and striatum) and spinal cord were observed at d 1, 3, 5 and 7, respectively.

Key words: Electroacupuncture;Analgesia;Tolerance;#kappa#-opioid receptor

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引用本文：

董艺娜, 毛慕华, 毛晓民, 韩济生. 100Hz电针耐受时大鼠脑和脊髓#kappa#受体结合特性的改变[J]. 生理学报 1998; 50 (6): .

Dong Yina, Mao Muhua, Mao Xiaomin, Han Jisheng. Changes in the binding characteristics of central #kappa#-opioid receptor during the development of 100Hz electroacupuncture (EA) tolerance in rats. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).