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颈动脉注射腺苷对去缓冲神经大鼠延髓腹外侧头端区神经元放电的影响

陈爽, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

在28只切断双侧缓冲神经的Sprague-Dawley大鼠,应用细胞外记录方法,观察了72个自发放电单位中颈动脉注射腺苷对延髓腹外侧头端(RVLM)区神经元自发放电活动的影响。结果提示,腺苷对RVLM区神经元自发放电有抑制作用,而此作用与A_(1)受体介导的ATP敏感性钾通道开放有关。

关键词： 腺苷; 延髓腹外侧头端区; 自发放电单位; 8-本茶碱; 8-环戊-1,3-二丙基黄嘌呤; 格列苯脲

Effect of intracarotid injection of adenosine on the activity of RVLM neurons in barodenervated rats

Chen Shuang, He Ruirong

Department of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

To observe the effect of intracarotid administration of adenosine of adenosine on neurons in the rostral ventrolateral medulla (RVLM) region, 72 spontaneous active units were extracellularly recorded from 28 Sprague-Dawley rats with sino-aortic denervation. Results indicate that Ado can induce an inhibition of spontaneous electrical activity of RVLM neurons, an effect which is mediated by adenosine A_(1)-receptor with the involvement of ATP-sensitive potassium channels.

Key words: Adenosine;Rostral ventrolateral medulla;Spontaneous single-unit discharge;8-phenyltheophylline;8-cyclopentyl-1, 3-dipropylxanthine;Glibenclamide

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引用本文：

陈爽, 何瑞荣. 颈动脉注射腺苷对去缓冲神经大鼠延髓腹外侧头端区神经元放电的影响[J]. 生理学报 1998; 50 (6): .

Chen Shuang, He Ruirong. Effect of intracarotid injection of adenosine on the activity of RVLM neurons in barodenervated rats. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).