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17#beta#-雌二醇对大鼠海马神经元延迟整流型钾离子通道活动的影响

摘要

1.0和10.0nmol/L E2可分别使42pS K~(+)通道开放概率由(67.4±18.2)%下降到(41.2±12.5)%和由(56.3±15.8)%下降到(13.2±12.6)%,通道开放频率由(43.40±6.7)Hz下降到(27.68±9.1)Hz和由(38.19±10.1)Hz下降到(15.79±3.5)Hz,通道平均开放时间缩短,平均关闭时间延长,但通道电流幅度无显著改变。

关键词： 17β-雌二醇; 钾离子通道; 海马神经元; 膜片箝

Effects of 17#beta#-estradiol on delayed rectifier potassium channels in hippocampal pyramidal neurons of the rat

Abstract

After application of 1.0 and 10.0nmol/L E2, the open probabilities of K~(+) channels were decreased from (67.4±18.2)% to (41.2±12.5)% and from (56.3±15.8)% to (13.2±12.6)% respectively, the open frequencies were reduced from (43.40±6.7)Hz to (27.68±9.1)Hz and from (38.19±10.1)Hz to (15.79±3.5)Hz respectively. Meanwhile, there was a shortening of the mean open time and a lengthtening of the mean close time of the channels.

Key words: 17#beta#-estradiol;Potassium channel;Hippocampal neuron;Patch-clamp

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引用本文：

. 17#beta#-雌二醇对大鼠海马神经元延迟整流型钾离子通道活动的影响[J]. 生理学报 1998; 50 (5): .

. Effects of 17#beta#-estradiol on delayed rectifier potassium channels in hippocampal pyramidal neurons of the rat. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).