过刊浏览

腺苷引起促黑素细胞膜电位超极化的离子机制

摘要

腺苷所致的细胞膜超极化是由于增加了非电压激活的钾离子通道的开放,而对超极化电压激活的内向阳离子电流(I_(h))没有影响。

关键词： 促黑素细胞; 膜片箝技术; K~(+)电流; I_(h)

The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs

Abstract

It has been previously shown that the activation of A_(1) adenosine receptors in frogmelanotroph induced a hyperpolarization accompanied by blockage of spontaneous action potentials. In the present report, we explored mechanisms underlying the above phenomenon using the pacth-clamp technique in whole-cell and cell-attached configuration. The result showed that adenosine could increase the opening of non-voltage-activated potassium channels leading to hyperpolarization, but an inward cation current activated by hyperpolarizing pulse was not involved.

Key words: Melanotroph;Patch-clamp technique;Potassium channel;I_(h)

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

. 腺苷引起促黑素细胞膜电位超极化的离子机制[J]. 生理学报 1998; 50 (5): .

. The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).