过刊浏览

#alpha#-黑色素细胞刺激素对白细胞介素-1#beta#发热的解热机理研究

摘要

观察了#alpha#-黑色素细胞刺激素(#alpha#-MSH)对家兔白细胞介素-1#beta#(IL-1#beta#)发热效应及下丘脑组织腺苷环磷酸(cAMP)含量的影响;同时观察了下丘脑组织体外培养过程中,#alpha#-MSH对IL-1#beta#刺激下丘脑释放cAMP的影响。

关键词： 黑色素细胞刺激素; 白细胞介素-1; 腺苷环-磷酸; 下丘脑; 发热

Studies on the mechanism of #alpha#-MSH in reducing IL-1#beta#-induced fever

Abstract

#alpha#-MSH markedly suppressed febrile response (P<0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1#beta# (P<0.01). The cAMP content of the medium in which the hypothalamic was incubated for 40 min in the presence of IL-1#beta# was significantly increased (P<0.01). However, this increase action could be prevented by a pretreatment with #alpha#-MSH.

Key words: Melanocyte-stimulating hotmone;Interleukin-1;Adenosine cyclic;Hypothalamus; Fever

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

. #alpha#-黑色素细胞刺激素对白细胞介素-1#beta#发热的解热机理研究[J]. 生理学报 1998; 50 (5): .

. Studies on the mechanism of #alpha#-MSH in reducing IL-1#beta#-induced fever. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).