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容量负荷性肥厚心肌中血管紧张素II-1型受体mRNA表达的动态变化

摘要

采用腹腔动-静脉瘘制造大鼠容量负荷增加所致心肌肥厚模型,应用反转录-聚合酶链式反应(RT-PCR)及同位素掺入技术,检测手术后不同时间点左、右心室(LV、RV)组织中AngII-1型受体的a亚型(AT1a)及b亚型(AT1b)mRNA的表达。结果提示:AT1a与AT1b mRNA表达的上调,可能是容量负荷增加所致中、后期肥厚心肌对AngII反应性增强的重要机制。而AT1a与AT1b两种亚型mRNA在容量负荷性肥厚心室组织中的不同表达,可能与其分别介导AngII不同的生理、病理作用有关。

关键词： 心肌肥厚; 血管紧张素Ⅱ; 受体

Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy

Abstract

The results suggest that the increased mRNA expression of AT1 in myocardial hypertrophy caused by volume overload may be a mechanism underlying the increased responsiveness of hypertrophic myocardial cells to Ang II, and a difference in the expression between AT1a and AT1b mRNAs in myocardial hypertrophy may be related to the different physiological or pathophysiological roles of Ang II, mediated by the two subtypes of AT1.

Key words: Ventricular hypertrophy;Angiotensin Ⅱ;Receptors

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引用本文：

. 容量负荷性肥厚心肌中血管紧张素II-1型受体mRNA表达的动态变化[J]. 生理学报 1998; 50 (3): .

. Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).