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大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响

摘要

PAG内微量注射OFQ可使大鼠痛阈降低,并明显对抗针刺镇痛;另外还发现,OFQ在PAG内还可以对抗#mu#受体激动剂羟甲芬太尼加强针刺镇痛的效应。

关键词： 孤啡肽; μ阿片受体; 中脑导水管周围灰质; 针刺镇痛; 痛

Effect of orphanin FQ on acupuncture analgesia and noxious stimulation in the periaqueductal gray

Abstract

The results show that the hyperalgesia of OFQ and its antagonization on AA in PAG are dose-related. OFQ in PAG decreases the enhancing effect on AA induced by ohmefentanyl, a selective #mu#-receptor agonist. These observations suggest that OFQ in PAG can increase the rat pain sensitivity and antagonize AA.

Key words: Orphanin Fo;#mu#-receptor;Acupuncture;Analgesia;Pain

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引用本文：

. 大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响[J]. 生理学报 1998; 50 (3): .

. Effect of orphanin FQ on acupuncture analgesia and noxious stimulation in the periaqueductal gray. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).