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白细胞介素-1#beta#对醋氨酚诱导的小鼠肝损伤具有保护作用

孙红, 李继尧, 于吉人

北京医科大学生理系.北京 100083

摘要

在提前12h这一时间点观察不同剂量(10 000、30 000、50 000U/kg)IL-1#beta#作用的结果表明,IL-1#beta#抑制醋氨酚诱导的转氨酶漏出呈一定的剂量-效应关系,还可不同程度地降低小鼠死亡率。IL-1#beta#受体拮抗剂可阻断IL-1#beta#的保护作用。对IL-1#beta#肝细胞保护作用机制的初步分析表明,IL-1#beta#可增加正常肝细胞还原型谷胱甘肽(GSH)含量并阻止醋氨酚诱导的GSH含量的降低和氧化型谷胱甘肽(GSSG)的增加,此外还可降低醋氨酚诱导的肝脏丙二醛含量的增加。结果表明,IL-1#beta#可预防醋氨酚诱导的肝损伤,可能由IL-1#beta#受体所介导,可能与增加谷胱甘肽合成和降低肝脏脂质过氧化有关。

关键词： 白介素-1β; 醋氨酚; 肝细胞保护

Protective effect of interleukin-1#beta# on acetaminophen induced liver damage in mice

Sun Hong, Li Jiyao, Yu Jiren

Department of Physiology, Beijing Medical University. Beijing 100083

Abstract

Treatment with IL-1#beta# of different doses (10 000, 30 000 or 50 000 U/kg) 12 h before the administration of acetaminophen could reduce the leakages of transaminases in a dose dependent manner and decrease the mortality of mice. The protective effect of IL-1#beta# on the liver could be abolished by IL-1#beta# receptor antagonist. Further experiments showed that IL-1#beta# could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen. IL-1#beta# could also reduce malondiadehyde (MDA) content enhanced by acetaminophen.

Key words: Interleukin-1#beta#;Acetaminophen;Hepatoprotection

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引用本文：

孙红, 李继尧, 于吉人. 白细胞介素-1#beta#对醋氨酚诱导的小鼠肝损伤具有保护作用[J]. 生理学报 1997; 49 (2): .

Sun Hong, Li Jiyao, Yu Jiren. Protective effect of interleukin-1#beta# on acetaminophen induced liver damage in mice. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).