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失血性休克早期白细胞介素1活性升高的机制--内毒素与白细胞介素1

石汉平, 缪明永, 秦路平, 高瀚, 徐仁宝

第一军医大学南方医院普外科.广东,广州 510515；第二军医大学生化教研室.上海 200433；第二军医大学生药教研室.上海 200433；第二军医大学病理生理教研室.上海 200433；第二军医大学长征医院普外科.上海 200002

摘要

失血性休克早期血浆IL-1及ET均明显升高,前者升高在先;无菌大鼠失血性休克后IL-1活性也升高,但ET无明显变化;预先给大鼠口服乳果糖以清洁肠道,或静注内毒素抗体,休克后血浆IL-1活性仍然明显升高,而血浆ET无明显升高;大鼠失血后1 h将失血回输,再灌注后5d血浆IL-1与ET呈平行性变化,乳果糖或抗内毒素抗体治疗后,血浆IL-1活性及ET水平均明显降低。

关键词： 失血性休克; 内毒素; 白细胞介素I

Modulation mechanism of IL-1 in hemorrhagic shock in relation to endotoxin

Shi Hanping, Miao Mingyong, Qin Luping, Gao Han, Xu Renbao

Departmant of General Surgery, The South Hospital, First Military Medical University. Guangzhou 510515, Guangdong

Abstract

The modulation mechanism of IL-1 in relation to endotoxin (ET) was investigated in hemorrhagic shock rat. It was found that within 4 h after hemorrhagic shock, SD rat showed a significant increase in both ET and IL-1, the latter taking place earlier than the former. While SD rat reared in germ free condition showed an obvious increas in IL-1 but without marked change in ET, no matter whether the rats reared in different condition were pretreated with lactulose or anti-ET. Within 5 d after reinfusion of lost blood to teh ordinary shock rat, IL-1 and ET changed in a parallel manner. When shock rats were treated with lactulose or anti-ET, both IL-1 and ET showed significant decrease as compared with the control. It is suggested from the above observation that ET is not an important factor in enhancing IL-1 activity in the later phase of hemorrhagic shock. The ET comes mainly from the gut in hemorrhagic state.

Key words: Hemorrhagic shock;Endotoxin;Interleukin-1

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引用本文：

石汉平, 缪明永, 秦路平, 高瀚, 徐仁宝. 失血性休克早期白细胞介素1活性升高的机制--内毒素与白细胞介素1[J]. 生理学报 1997; 49 (2): .

Shi Hanping, Miao Mingyong, Qin Luping, Gao Han, Xu Renbao. Modulation mechanism of IL-1 in hemorrhagic shock in relation to endotoxin. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).