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大鼠内毒素血症不同时期血浆CGRP和背根神经节CGRP mRNA水平的变化

唐跃明, 韩启德, 邢宇彤, 白燕, 王宪

北京医科大学第三医院血管医学研究所.北京 100083

摘要

注射内毒素(5 mg/kg)后30min时,大鼠血浆降钙素基因相关肽(CGRP)开始增高,而背根神经节CGRP mRNA水平无明显变化;注射内毒素后3 h时,血浆CGRP及背根神经节CGRP mRNA均明显增高,分别为142％和32％,8h时则进一步增高,分别为216％和85％。提示内毒素不仅刺激外周组织释放CGRP,而且还能通过某些机制激活背根神经节CGRP mRNA的转录,使CGRP合成增加,以作为CGRP大量释放的重要补充来源。

关键词： 内毒素血症; 背根神经节; 降钙素基因相关肽（CGRP）; mRNA

Changes of CGRP levels in plasma and CGRP mRNA in dorsal root ganglia during endotoxicosis in the rat

Tang Yueming, Han Qide, Xing Yutong, Bai Yan, Wang Xian

Institute of Vascular Medicine, The Third Hospital, Beijing Medical University. Beijing 100083

Abstract

The results showed that plasma CGRP, but not mRNA, began to increase 30 min after endotoxin (5 mg/kg, i.v.) administration. On the other hand, the CGRP levels in plasma and CGRP mRNA in DRG were significantly increased by 142% and 32% respectively at the 3 h of injection and by 216% and 85% respectively at the 8 h of injection.

Key words: Endotoxicosis;Dorsal root ganglia;Calcitonin gene-related peptide;mRNA

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引用本文：

唐跃明, 韩启德, 邢宇彤, 白燕, 王宪. 大鼠内毒素血症不同时期血浆CGRP和背根神经节CGRP mRNA水平的变化[J]. 生理学报 1997; 49 (2): .

Tang Yueming, Han Qide, Xing Yutong, Bai Yan, Wang Xian. Changes of CGRP levels in plasma and CGRP mRNA in dorsal root ganglia during endotoxicosis in the rat. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).