过刊浏览

延髓头端腹外侧区注入肾上腺素对血液流变学的影响

王石洪, 郭学勤

上海医科大学生理学教研室.上海 200032

摘要

清醒大鼠束缚2d可引起应激性高血粘度和血压升高。双侧延髓头端腹外侧区(rVLM)微量注射肾上腺素(E,每侧0.5#mu#g/0.5#mu#l)可引起血粘度明显增高,此作用可预先在双侧rVLM注入#alpha#-肾上腺素能受体阻断剂酚妥拉明所阻断,不能被#beta#-肾上腺能受体阻断剂心得安所阻断。用同样剂量E注入双侧延髓尾端腹外侧区或静脉内,无上述作用。在双侧rVLM区内注入6-羟多巴胺可降低应激性高血粘度。在双侧rVLM区内注入酚妥拉明可降低应激性高血粘度,而注入心得安无此作用。

关键词： 肾上腺素; 延髓头端腹外侧区; 应激; 高血粘度

Effect of microinjection of adrenaline (E) into the rostral ventrolateral medulla on the parameters of the hemorrheology

Wang Shihong, Guo Xueqin

Department of Physiology, Shanghai Medical University. Shanghai 200032

Abstract

Experiments were performed on SD rats. It was found that hyperviscosity could be induced by restrained conscious rats. Microinjection of adrenaline (E) into the rostral ventrolateral medulla (rVLM) resulted in a facilitatory increase in blood viscosity, which was blocked by bilateral microinjection of #alpha#-adrenoceptor antagonist (phentola mine) into the same area, but not by #beta#-adrenocetor antagonist (propranolol). Pretreatment of rVLM area with 6-hydroxydopamine (6-OHDA) or microinjection of phentolamine abolished stress-induced hyperviscosity, while propranolol was without effect. Apparently the E caused increase of the blood viscosity or stress-induced hyperviscosity may be mediated by activation of #alpha#-adrenoceptor in the rVLM.

Key words: Adrenaline;Rostral ventrolateral medulla;Stress;Hyperviscosity

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

王石洪, 郭学勤. 延髓头端腹外侧区注入肾上腺素对血液流变学的影响[J]. 生理学报 1997; 49 (2): .

Wang Shihong, Guo Xueqin. Effect of microinjection of adrenaline (E) into the rostral ventrolateral medulla on the parameters of the hemorrheology. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).