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肾上腺髓质素对大鼠肠系膜微血管和微淋巴管的作用

樊贵, 牛春雨, 韩敏, 张静, 魏英杰, 唐朝枢, 汤健

张家口医学院病理生理教研室.河北,张家口 075029；北京医科大学心血管基础研究所.北京 100083

摘要

活体显微电视录象技术观察表明,肾上腺髓质素(ADM)直接扩张肠系膜各级微血管和微淋巴管,拮抗去甲肾上腺素和内皮素引起的微血管效应及微循环血液流态的异常改变。ADM的上述作用可被一氧化氮生成抑制剂N~(G)-nitro-L-arginine显著抑制。

关键词： 肾上腺髓质素; 去甲肾上腺素; 内皮素; 微血管; 微淋巴管; 一氧化氮

Effect of adrenomedullin on mesenteric microvessels and microlymphatics in rat

Fan Gui, Niu Chunyu, Han Min, Zhang Jing, Wei Yingjie, Tang Shaoshu, Tang Jian

Department of Pathophysiology, Zhangjiakou Medical College.Zhangjiakou 075029, Hebei；China

Abstract

The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 amino acids, on the mesenteric microvessels andmicrolymphatics was investigated under microscopic observation. 10~(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10~(-5) mol/L morepinephrine (NE) or 10~(-7) mol/L endothelin (ET). However, this ameliorative response was markedly inhibited in the presence of N-nitro-L-arginine (L-NNA), an inhibitor for production of nitric oxide.

Key words: Adrenomedullin;Norepinephrine;Endothelin;Microvessels;Microlymphhatics;Nitric oxide

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引用本文：

樊贵, 牛春雨, 韩敏, 张静, 魏英杰, 唐朝枢, 汤健. 肾上腺髓质素对大鼠肠系膜微血管和微淋巴管的作用[J]. 生理学报 1997; 49 (1): .

Fan Gui, Niu Chunyu, Han Min, Zhang Jing, Wei Yingjie, Tang Shaoshu, Tang Jian. Effect of adrenomedullin on mesenteric microvessels and microlymphatics in rat. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).