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压力超负荷诱导左心室原癌基因c-fos的表达

谭定定, 钟春宁, 陈伟红, 潘敬运, 胡本荣

中山医科大学分子生物学实验室. 广东, 广州 510089；中山医科大学受体实 验室. 广东, 广州 510089

摘要

在腹主动脉缩窄 的大鼠上, 探讨压力超负荷对左心室原癌基因c-fos的表达。观察到压力超负荷可引起c-fos的明显表达, 该作用可被巯甲丙脯酸显著减弱。检测到压力超负荷时左心室血管紧张素原的表达也增强。

关键词： 压力超负荷; c－fos; 巯甲丙脯酸; 血管紧张素原

Expression of c-fos mRNA induced by pressure overload in the left ventricle

Tan Dingding, Zhong Chunning, Chen Weihong, Pan Jingyun, Hu Benrong

Laboratory of Molecular Biology, Sun Yat-Sen University of Medical Sciences. Guangzhou 510089, Guangdong； China

Abstract

In the present study the effect of pressure overload on the expression of protooncogene c-fos in the left ventricle was investigated in rats with abdominal aorta constriction. It was found that a remarkable expression of c-fos was induced by pressure overload and the expression was greatly attenuated by angiotensin converting enzyme inhibitor captopril. In the pressure overload group the angiotensinogen mRNA level was found increased. The above results suggest that angiotensin II is involved in the expression of c-fos due to pressure overload.

Key words: Pressure overload;c-fos;Captopril;Angiotensinogen

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引用本文：

谭定定, 钟春宁, 陈伟红, 潘敬运, 胡本荣. 压力超负荷诱导左心室原癌基因c-fos的表达[J]. 生理学报 1996; 48 (1): .

Tan Dingding, Zhong Chunning, Chen Weihong, Pan Jingyun, Hu Benrong. Expression of c-fos mRNA induced by pressure overload in the left ventricle. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).