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辣椒素敏感传入神经和NO中介胃内蛋白胨引起的酸和血流增加效应

阎长栋, 顾洛, 陈闽, 田苏平, 李栋生

南京医科大学生理教研室. 江苏, 南京 210029

摘要

采用氢气清除法 测定胃粘膜血流以及sc大剂量辣椒素使传入神经“去神经”的技术, 观察了大鼠胃内灌注蛋白胨引起胃酸分泌过程中胃粘膜血流量的变化以及传入神经在这一效应中的作用。表明辣椒素敏感传入神经成分和NO参与胃内蛋白胨引起的胃酸分泌及胃粘膜血流增多效应, 而胃粘膜血流增多效应可以通过胆碱能成分和非胆碱能成分中介。

关键词： 辣椒素敏感传入神经; 一氧化氮; 蛋白胨; L－NAME; 胃粘膜血流量; 氢气清除率

Capsaicin-sensitive afferent neurons and endogenous nitric oxide (NO) mediate the gastric acid secretion and hyperemic responses to intragastric peptone

Yan Changdong, Gu Luo, Chen Ming, Tian Suping, Li Dongsheng

Department of Physiology, Nanjing Medical University. Nanjing 210029, Jiangsu

Abstract

Using hydrogen gas chearance technique to measure gastric mucosal blood flow(GMBF) and a high dose of capsaicin to ablate the capsaicin-sensitive afferent neurons, the role of capsaicin-sensitive neurons in the gastric acid secretion and hyperemic response to intragastric peptone was investigated. These results suggested that capsaicin-sensitive afferent neurons and endogenous NO were involved in the gastric acid secretion and hyperemic response to intragastric peptone and the hyperemic response was mediated by both cholinergic and noncholinergic neurons.

Key words: Capeicin-sensitive afferent neurones;Nitric oxide （NO）;Peptone;;;

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引用本文：

阎长栋, 顾洛, 陈闽, 田苏平, 李栋生. 辣椒素敏感传入神经和NO中介胃内蛋白胨引起的酸和血流增加效应[J]. 生理学报 1996; 48 (1): .

Yan Changdong, Gu Luo, Chen Ming, Tian Suping, Li Dongsheng. Capsaicin-sensitive afferent neurons and endogenous nitric oxide (NO) mediate the gastric acid secretion and hyperemic responses to intragastric peptone. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).