过刊浏览

两组不同月龄小鼠学习记忆能力与脑突触体内游离[Ca~(2+)]_(i)的相关性

杜红燕, 张维宁, 章子贵, 邵悦, 王良斌, 王金Xi, 吴馥梅

南京大学 生物科学与技术系. 江苏, 南京 210093；南京大学配位化学国家重点实验 室. 江苏, 南京 210093

摘要

随着年龄的增长, 小鼠的分辨学习及记忆能力均下降, 同时海马突触体内游离[Ca~(2+)]_(i)升高显著。

关键词： 小鼠; 学习记忆; 脑突触体; ［Ca~（2＋）_(i)

Correlation between ability of learning-memory and synaptosomal free [Ca~(2+)]_(i) in mice of different age

Du Hongyan, Zhang Weining, Zhang Zigui, Shao Yue, Wang Liangbin, Wang Jinxi, Wu Fumei

Department of Biological Science and Technology, Nanjing University. Nanjing 210093, Jiangsu； China

Abstract

In the present investigation, the behavior of learning and memory of 1-month and 6-month-old mice was studied by using Y-maze and one-trial passive avoidance response device. The synaptosomal free [Ca~(2+)]_(i) of four main brain regions (Hippocampus, Cerebral cortex, Cerebellum, Tectum of midbrain)of these mice were measured by fluorescent probe Ca~(2+) indicator Fura-2 and an AR-CM-MIC cation measurement system. The results showed that, in comparison with 1-month-old mice, the ability of discrimination learning and memory of 6-month-old ones were attenuated, and the synaptosomal free [Ca~(2+)]_(i) of hippocampus was increased.

Key words: Mice;Learning and memory;Brain synaptosome;[Ca￣（2+）]_(i)

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

杜红燕, 张维宁, 章子贵, 邵悦, 王良斌, 王金Xi, 吴馥梅. 两组不同月龄小鼠学习记忆能力与脑突触体内游离[Ca~(2+)]_(i)的相关性[J]. 生理学报 1996; 48 (1): .

Du Hongyan, Zhang Weining, Zhang Zigui, Shao Yue, Wang Liangbin, Wang Jinxi, Wu Fumei. Correlation between ability of learning-memory and synaptosomal free [Ca~(2+)]_(i) in mice of different age. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).