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(-)SPD和(-)THP对蓝斑核去甲肾上腺素能神经元自发放电的影响

吴建华, 金国章

中科院上海药物研究所. 上 海 200031

摘要

(-)SPD通过去甲肾 上腺素#alpha#_(2)受体, 以剂量依赖方式增强蓝斑核神经元 放电, 但较大剂量却对神经元放电有一定抑制。然而(-)THP可使蓝斑核去甲肾上腺素能 神经元出现可逆性放电抑制。

关键词： 蓝斑; 单位放电; (－)千金藤啶碱; (－)四氢巴马汀

Effects of (-)SPD and (-)THP on the firing of noradrenergic neurons in locus coeruleus

Wu Jianhua, Jin Guozhang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031

Abstract

The effects of (-)SPD and (-)THP on the noradrenergic neurons in rat locus coeruleus were investigated by recording the in vivospontaneous firing . It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on #alpha#_(2) autoreceptors in a dose-dependent manner, while #alpha#_(2) receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory firing of the neurons, however, irreversible.

Key words: Locus coeruleus;Unit firing;(-)stepholidine;(-)tetrahydropalmatine

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引用本文：

吴建华, 金国章. (-)SPD和(-)THP对蓝斑核去甲肾上腺素能神经元自发放电的影响[J]. 生理学报 1995; 47 (6): .

Wu Jianhua, Jin Guozhang. Effects of (-)SPD and (-)THP on the firing of noradrenergic neurons in locus coeruleus. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).