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机体内环境理化因素对降钙素基因相关肽(CGRP)释放的影响

吴中欣, 韩启德, 白燕, 王宪

北京医科大学第三临床医院. 北京 100083

摘要

在离体大鼠肠系膜动脉床灌流的模型上, 发现低pH、高乳酸、高氯化钠和高蔗糖溶液 均能直接引起CGRP释放增加, 进一步应用辣椒素预灌流, CGRP释放的作用被抑制, 同时 CGRP释放可以被一种钙引起的细胞内钙池释放阻断剂钌红所抑制, 而且应用无钙的低pH,高乳酸及高渗液就不能引起CGRP释放增多。

关键词： 降钙素基因相关肽; 辣椒素; 肠系膜动脉

Effects of some physical and chemical factors on CGRP release from mesenteric arterial bed

Wu Zhongxin, Han Qide, Bai Yan, Wang Xian

Third Hospital, Beijing Medical University. Beijing 100083

Abstract

It was observed that low pH, elevated levels of lactic acid, hypertonic NaCl and hypertonic sucrose caused CGRP release from isolated mesenteric arterial bed (MAB) of rat. All the responses were blocked when MAB was pretreated with capsaicin. Ruthenium red, an inhibitor of Ca~(2+)-induced Ca~(2+) release from intracellular Ca~(2+) pools, significantly inhibited the release of CGRP. In Ca~(2+)free medium, low pH, lactic acid and hypertonic solutions became no longer capable of inducing the release of CGRP. It suggest that the observed release of CGRP in MAB was mediated by capsaicin-sensitive sensory nerve endings, as a result of Ca~(2+)-induced Ca~(2+) release from the intracellular Ca~(2+) store which is sensitive to ruthenium red.

Key words: Calcitonin gene-related peptide;Capsaicin;Mesenteric arterial bed

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引用本文：

吴中欣, 韩启德, 白燕, 王宪. 机体内环境理化因素对降钙素基因相关肽(CGRP)释放的影响[J]. 生理学报 1995; 47 (6): .

Wu Zhongxin, Han Qide, Bai Yan, Wang Xian. Effects of some physical and chemical factors on CGRP release from mesenteric arterial bed. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).