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一次给予红藻氨酸对大鼠脑内细胞信息传递通路及癫痫敏感性的作用

高溪, 张万琴, Hong Janshyong

大连医科大学生理教研室. 辽宁, 大连 116027；美国国立环境卫生研究院

摘要

实验组和对照组动物脑内细胞信息传递通路相同, 实验组动物海马内c-fos, c-jun 基因表达呈非同步加速; 海马邻近脑区内嗅皮层激活加速, 海马及Ent等部位前脑啡肽 原mRNA合成明显增加。

关键词： 红藻氨酸; 海马; c－Fos; c－Jun; 前脑啡肽原mRNA; 癫痫敏感性

The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure

Gao Xi, Zhang Wanqin, Hong Janshyong

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning； USA

Abstract

Sprague-Dawley(S.D.)rats were pretreated with kainic acid(KA,10mg/kg, i.sc.)72 days before either deep prepyriform cortex(DPC)kindling or injection of the same dose of KA. The results showed that such pretreatment accelerated the process of kindling, and the KA-induced seizures appeared more severe in behaviours. c-Fos-immunoreactivity(c-Fos-ir)was used to demonstrate the neuronal activity in central nervous system during the provocative dose of KA-induced seizure, as comparing with the control which received normal saline of KA 72 days ago. The results indicated that, the tansmission pathways in two groups were just the same; but the time courses of c-fos and c-jun expression in KA pretreated group were accelerated asynchronously; and the synthesis of the proenkephalin mRNA in the Ent was apparently up-regulated.

Key words: Kainic acid;Hippocampus;c-jun;Proenkephalin mRAN;Susceptibility ;

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引用本文：

高溪, 张万琴, Hong Janshyong. 一次给予红藻氨酸对大鼠脑内细胞信息传递通路及癫痫敏感性的作用[J]. 生理学报 1995; 47 (6): .

Gao Xi, Zhang Wanqin, Hong Janshyong. The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).