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8％-9％和12％-13％低氧气体诱导大鼠左右心室肌自由基增殖

韩沾元, 陈铭, 闻萍, 王庆华

中科院上海生理研究所. 上海 200031；上海医药工业研究院制剂研究室. 上海 200040

摘要

低氧诱导大鼠左右心肌自由基增殖过程中, 左心肌先于右心肌, 左心肌增殖的主要是 超氧自由基, 低氧中途复氧导致部分增殖自由基被清除。低氧期间心肌SOD酶活性下降可能是心肌自由基增殖途径之一。

关键词： α－苯基－N－叔丁基甲亚胺－N－氧化物; 超氧化物歧化酶; 自由基; 心肌; 丙二醛

8%-9% and 12%-13% hypoxic gas induced free radicals generation in rat^s left and right myocardium

Han Zhanyuan, Chen Ming, Wen Ping, Wang Qinghua

Physiological Laboratory of Hypoxia, Shanghai Institute of Physiology, Chinese Academy of Sciences. Shanghai 200031；China

Abstract

Alpha-phenyl-tert-butylnitrone (PBN) was administered intravenously to capture free radicals of rat^s myocardium. Rats were exposed to hypoxic gas (8%-9% O_(2) in N_(2) for 15min. The results suggested that one way of myocardium free radical gereration may be relevant to decrease of SOD activity. The generation of free radicals pertained chiefly to superoxide free radical in the left myocardium and the membrane structure of myocardium cells might have been damaged largely during hypoxia.

Key words: #alpha#-phenyl-tert-I-butylnirone;Superoxide dismutase;Free radicals; Myocardium;Malondialdehyde

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引用本文：

韩沾元, 陈铭, 闻萍, 王庆华. 8％-9％和12％-13％低氧气体诱导大鼠左右心室肌自由基增殖[J]. 生理学报 1995; 47 (5): .

Han Zhanyuan, Chen Ming, Wen Ping, Wang Qinghua. 8%-9% and 12%-13% hypoxic gas induced free radicals generation in rat^s left and right myocardium. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).