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损毁或刺激垂体和下丘脑弓状核对大鼠痛觉调制的影响

陈起亮, 李金华, 周志菁, 印其章

苏州医学院生理学教研室. 江苏,苏州 215007

摘要

损毁垂体中间叶和前叶能降低基础痛阈, 取消刺激下丘脑弓状核(ARC)即刻出现的镇痛作用。刺激垂体的相同部位能提高基础痛阈, 并出现有一定潜伏期的镇痛作用, 该镇痛作用能被损毁ARC所阻断。

关键词： 损毁; 刺激; 垂体; 下丘脑弓状核; 痛阈; 痛觉调制

Effects of lesion or stimulation of pituitary gland and hypothalamic arcuate nucleus on pain modulation in rats

Chen Qiliang, Li Jinhua, Zhou Zhijing, Yin Qizhang

Department of Physiology, Suzhou Medical College. Suzhou 215007,Jiangsu

Abstract

Relationship between pituitary gland and hypothalamic arcuate nucleus (ARC) in the modulation of pain threshold was investigated in Wistar rats with method of focal lesion and stimulation of pituitary gland. Experimental results indicated that electrolytic lesion of the pituitary intermediate and anterior lobes resulted in a decrease of pain threshold and disappearnce of the analgesia immediately produced by ARC stimulation. Stimulation of the same area of pituitary gland could induce a delayed analgesia, which could be blocked by ARC lesion.

Key words: Lesion;Stimulation;Pituitary gland;Hypothalamic arcuate nucleus;Pain threshold;Pain modulation

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引用本文：

陈起亮, 李金华, 周志菁, 印其章. 损毁或刺激垂体和下丘脑弓状核对大鼠痛觉调制的影响[J]. 生理学报 1995; 47 (5): .

Chen Qiliang, Li Jinhua, Zhou Zhijing, Yin Qizhang. Effects of lesion or stimulation of pituitary gland and hypothalamic arcuate nucleus on pain modulation in rats. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).