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刺激下丘脑弓状核或垂体前叶对丘脑束旁核神经元伤害性反应的抑制

矫勇益, 端木肇夏, 俞光第, 印其章

苏州医学院神经生物学研究室. 江苏,苏州 215007

摘要

电刺激大鼠下丘脑弓状核(ARC)能抑制丘脑束旁核(Pf)神经元的伤害性放电, 该抑制 很快出现, 也很快恢复, 称为即时抑制。电刺激垂体前叶(AL)也能抑制Pf神经元的伤害 性放电, 该抑制的出现有一定的潜伏期, 并持续较长时间, 称为延迟抑制。摘除垂体减 弱刺激ARC的即时抑制, 而损毁ARC则减弱刺激AL的延迟抑制。地塞米松预处理, 可阻断 上述两种抑制。

关键词： 下丘脑弓状核; 垂体; 丘脑束旁核; 单位放电; 地塞米松; β－内啡肽; 镇痛

Inhibitory effects of hypothalamic arcuate nucleus or anterior pituitary stimulation on the nociceptive responses of thalamic parafascicular neurons

Jiao Yongyi, Duanmu Zhaoxia, Yu Guangdi, Yin Qizhang

Laboratory of Neurobiology, Suzhou Medical College. Suzhou 215007, Jiangsu

Abstract

ARC stimulation could inhibit the nociceptive discharges of Pf neurons , namely, the immediate inhibition because of its very short latency and duration. AL stimulation could also inhibit the nociceptive discharges of Pf neurons, but this inhibition was a delayed one because of its longer latency and duration. Hypophysectiomy diminished the immediate inhibition due to ARC stimulation, while ARC lesion diminished the delayed inhibition due to AL stimulation. Both kinds of inhibition were blocked by dexamethasone pretreatment. The above results suggest that neuroendoerine relationship between ARC and AL is involved in pain modulation.

Key words: Hypothalamic arcuate nucleus;Pituitary;Thalamic parafascicular nucleus;Unit discharges;Dexamethasone;#beta#-endorphin;Analgesia

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引用本文：

矫勇益, 端木肇夏, 俞光第, 印其章. 刺激下丘脑弓状核或垂体前叶对丘脑束旁核神经元伤害性反应的抑制[J]. 生理学报 1995; 47 (5): .

Jiao Yongyi, Duanmu Zhaoxia, Yu Guangdi, Yin Qizhang. Inhibitory effects of hypothalamic arcuate nucleus or anterior pituitary stimulation on the nociceptive responses of thalamic parafascicular neurons. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).