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缩胆囊素和促胰液素对豚鼠离体胃平滑肌运动的影响

瞿颂义, 郑天珍, 李伟

兰州医学院生理教研室. 甘肃, 兰州 730000

摘要

用8个肌槽同时记录豚鼠胃不同部位肌条的收缩活动, 以观察八肽缩胆囊素(CCK-8)和促胰 液素的影响。结果表明: CCK-8能增高各部位纵行肌和环行肌的张力, 加快胃体纵行肌, 胃窦纵行肌环行肌、和幽门环行肌的收缩频率, 增大胃窦环行肌收缩波平均振幅以及增加幽门环行肌收缩波运动指数, 但减少胃体和胃窦纵行肌收缩波平均振幅。这些作用均不能被阿托品和消炎痛所阻断。而促胰液素对各部位肌条的收缩活动无明显的影响。图1表2参7

关键词： 八肽缩胆羹素; 促胰液素; 胃平滑肌; 阿托品; 消炎痛

Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs

Qu Songyi, Zheng Tianzhen, Li Wei

Department of Physiology, Lanzhou Medical College. Lanzhou 730000, Gansu

Abstract

Motility of gastric strips taken from different regions of guinea pig stomach were simultaneously recorded in 8 tissue chambers to test the effect of cholecystokinin--octapeptide (CCK--*) and secretin. It was found that CCK--8 could increase (1) all regional circular and longitudinal muscular tension at rest, (2) the frequency of contractions in body, antrum and pylorus (3)the mean contractole amplitude of antral circular strips, (4) the motility index of pylorus, but decrease the mean contractile amplitude of body and antral longitudinal strips. All the CCK--8 effects could not be blocked by atropine or indomethacin. Secretin was without effect on gastric smooth muscle activity.

Key words: Cholecystokinin-octapeptide (CCK-8);Secretin;Gasiric smooth muscle;Atropine;Indomethacin

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引用本文：

瞿颂义, 郑天珍, 李伟. 缩胆囊素和促胰液素对豚鼠离体胃平滑肌运动的影响[J]. 生理学报 1995; 47 (3): .

Qu Songyi, Zheng Tianzhen, Li Wei. Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).