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侧脑室内注射五肽胃泌素对大鼠血压和心率的影响

王明江, 黄承钧, 张功寿

郧阳医学院生理学教研室. 湖北, 十堰 442000；同济医科大学生理学教研室. 湖北, 武汉

摘要

以动脉血压和心率作为指标, 在氨基甲酸乙酯麻醉、三碘季铵酚制动、呼吸机控制呼吸的SD大鼠上, 观察到侧脑室内注射五肽胃泌素(G_(5), 4#mu#g)后动脉血压升高, 心率增加 。而侧脑室注射生理盐水或iv同剂量的G_(5)对上述指标均无影响。侧脑预先注射#alpha#受体阻断剂酚妥拉明(10#mu#g),可部分拮抗G_(5),对血压和心率的增加效应; 而预先注射#beta#受体阻断剂心得安(4#mu#g)或M受体阻断剂阿托品(4#mu#g)对G_(5)的血压和心率增加效应均无影响。结果表明G_(5)具有中枢性升高动脉血压和心率的作用, 此作用可能部分由脑内#alpha#受体介导。图3参14

关键词： 五肽胃泌素; 侧脑室; 血压; 心率; 酚妥拉明

Effects of pentagastrin with intracerebro-ventricular injection on blood pressure and heart rate in rats

Wang Mingjiang, Huang Chengjun, Zhang Gongshou

Department of Physiology, Yunyang Medical College. Shiyan 442000, Hubei；China

Abstract

Experiments were carried out on 84 artifially ventilated SD rats anaesthetized with urethane and immobilized with gallamine triethiodide. Injection of pentagastrin (G_(5)) into the rat lateral ventride resulted in a marked elevation in arterial blood pressure which reached its peak at 3 min (from 12.2±1.5 to 14.1 ±1.7kPa) and also a significant increase in heart rate from 435±53.2 beats/min. This effect of G_(5)could be parially antagonized by injection of phentolaine (#alpha# antagonist, 10#mu#g) into the lateral ventricle, but not by propanolol (#beta receptor antagonist, 4#mu#g) or atropine (M--receptor antagonist, 4#mu#g). These findings indicate that the central effect of G_(5)on blood pressure and heart rate is partly mediated by #alpha#--receptor.

Key words: Pentagstrin;Intracerebro-ventricular;Blood pressure;Heart rate;Phentolamine

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引用本文：

王明江, 黄承钧, 张功寿. 侧脑室内注射五肽胃泌素对大鼠血压和心率的影响[J]. 生理学报 1995; 47 (3): .

Wang Mingjiang, Huang Chengjun, Zhang Gongshou. Effects of pentagastrin with intracerebro-ventricular injection on blood pressure and heart rate in rats. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).