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分别兴奋大鼠内侧和外侧缰核引起痛阈的不同改变

赵华, 王绍

白求恩医科大学生理教研室. 吉林, 长春 130021

摘要

在戊巴比妥钠浅麻和清醒的大鼠上进行实验, 应用玻璃微电极微量注射L-谷氨酸(L-Glu) 到内侧缰核(MHb)和外侧缰核(LHb), 利用多种动物模型观察大鼠的痛阈改变, 发现兴奋MHb 时痛阈增高, 而LHb兴奋时痛阈降低。图4参10

关键词： 缰核; 痛阈; 边缘系统; L－谷氨酸

Different effect on L-glutamate microinjection into medial or lateral habenular nucleu on pain threshold

Zhao Hua, Wang Shao

Department of Physiology, Norman Bethune University of Medical Sciences. Changchun 130021, Jilin

Abstract

The habenulae (Hb) are related to modulation of pain sensation, but the results from different laboratories are inconsistant. The aim of the present investigation is to clarify the dicrepancy. L--Glutamic acid (L--Glu) was microinjected into medial (MHb) and lateral habenular nucleus (LHb) on light anesthetized or conscious rats, and pain threshold was then determined on the different models of animal The results showed that the activation of MHb increased TFL, whereas activation of LHb decreased TFL.

Key words: Habenulae;Tail-flick latency;Limbic system;L-Glutamic acid

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引用本文：

赵华, 王绍. 分别兴奋大鼠内侧和外侧缰核引起痛阈的不同改变[J]. 生理学报 1995; 47 (3): .

Zhao Hua, Wang Shao. Different effect on L-glutamate microinjection into medial or lateral habenular nucleu on pain threshold. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).