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急性低氧对大鼠血粘度、红细胞变形能力和左心室功能的影响

李新波, 郭学勤, 梁子钧

上海医科大学生理学教研室. 上海 200032；上海医科大学生物物理教研室. 上海 200032

摘要

健康SD雄性大鼠, 麻醉、气管插管, 用人工呼吸机经气袋供气, 自发吸入氧浓度为9%的氧氮混合气, 用SMUP-PC生物信号处理系统处理左心室功能。结果: (1)急性低氧经动脉血气分 析可见PaO_(2)下降, pH值升高, PaCO_(2)稍下降, 左心室功能各指标均下降; 血 液流变学指标升高, 红细胞滤过指数升高;复氧后各指标恢复正常。(2)iv心得安后, 使急性低氧诱发的左心室功能各指标更加明显下降, 而血液流变学各值不再明显上升; iv酚妥拉明后, 使急性低氧诱发的血液流变学各值上升不明显。(3)石炭酸破坏双侧颈劝脉窦区后也可 致低氧诱发的左心室功能各指标进一步下降, 而血液流变学指标也不明显上升。表5参14

关键词： 急性低氧; 血粘度; 左心室功能; 红细胞变形性

Effect of acute hypoxia on blood viscosity, red blood cell deformability and the left ventricular function in rats

Li Xinbo, Guo Xueqin, Liang Zijun

Department of Physiology, Shanghai Medical University. Shanghai 200032；China

Abstract

The left ventricular function and the parameters of hemorrheology during acute hypoxia were investigated. It was found that during acute hypoxia of 15 min, arterial blood gas value PaO_(2) decreased markedly. The parameters of the left ventricular function such as ±dP/dt_(max), Peak, HR, Vce40, Vmp, V_(max), LO(CFU), decreased markedly either. At the same time, hyperviscosity was induced and red blood cell filtration (IF)increased. All these parameters recovered to normal level after reoxgenation of 15 min. By intravenous injection of propranolol (0.5mg/kg) and then hypoxia, the left ventricular function were suppressed markedly; and so were to the elevation of blood viscosity and IF. Preinjection of regitine (3 mg/kg)prior hypoxia has the same effect on the blood viscosity and IF. Acute hypoxia induced hyperviscosity and elevation of IF could be suppressed by destruction of carotid sinus region with phenol, but the left ventricular function decreased markedly.

Key words: Acute hypoxia;Blood viscosity;Lleft ventricular function;Red blood cell deformability

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引用本文：

李新波, 郭学勤, 梁子钧. 急性低氧对大鼠血粘度、红细胞变形能力和左心室功能的影响[J]. 生理学报 1995; 47 (2): .

Li Xinbo, Guo Xueqin, Liang Zijun. Effect of acute hypoxia on blood viscosity, red blood cell deformability and the left ventricular function in rats. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).