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伏核在躯体传入冲动抑制防御性心血管反应中的作用及机制

樊一平, 张荣宝

浙江医科大学生理学教研室. 浙江, 杭州 310006

摘要

损毁伏核可明显削弱电刺激腓深神经(DPN)对兴奋下丘脑背内侧核诱发的升压反应和心肌缺 血的抑制作用(P<0.05、P<0.01)。电刺激伏核可引起明显的降压效应。中脑中央灰质 腹侧部(vPAG)微量注射纳洛酮可明显衰减伏核的减压效应; 损毁vPAG甚至可翻转伏核的减压效应, 引起轻度升压(P<0.01)。损毁弓状核后伏核的减压效应基本消失; 弓状核内微量 注射纳洛酮明显衰减伏核的减压效应。故DPN传入冲动可能通过伏核-弓状核-vPAG通路, 继而下行抑制延髓、脊髓心血管中枢, 内阿片肽参于伏核对弓状核与vPAG的调节过程。图3 表2参14

关键词： 伏核; 弓状核; 中脑中央灰质腹侧部; 腓深神经; 防御性心血管反应; 降压反应

The role of accumbens nucleus in the inhibitory effect of somatic aferent inputs on the defence cardiovascular response and its mechanism

Fan Yiping, Zhang Rongbao

Department of Physiology, Zhejiang Medical University. Hangzhou 310006, Zhejiang

Abstract

After Accumbens Nucleus (AC) lesion, the inhibitory effect of deep peroneal nerve (DPN) on the pressor response and ECG--ST changes induced by excitation of dorsomedial nucleus of hypothalamus (DMH) was decreased as compared with that of before lesion (P<0.05, P<0.01). Electrical stimulation of AC could elicit prominent depressor response, which could be effectively lessened by microinjection of naloxone into ventral periaqueductal gray (vPAG). Lesion of vPAG could reverse the depressor response to AC stimulation to a slight pressor response (P<0.01). AFter lesion of arcuate nucleus of hypothalamus (ARC), the depressor response to AC stimulation almost disappeared, which, again, could be largely mimicked by microinjection of naloxone inti ARC.

Key words: Accumbens nucleus;Arcuate nucleus;Ventral periaqueductal gray;Deep peroneal nerve;Depressor response;Defence cardiovascular response

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引用本文：

樊一平, 张荣宝. 伏核在躯体传入冲动抑制防御性心血管反应中的作用及机制[J]. 生理学报 1995; 47 (2): .

Fan Yiping, Zhang Rongbao. The role of accumbens nucleus in the inhibitory effect of somatic aferent inputs on the defence cardiovascular response and its mechanism. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).