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黄鼠下丘脑视前区NE能神经支配对冬眠阵的调制

方晓红, 蔡益鹏

北京大学生物系. 北京 100871

摘要

侧脑室注射6-OH DA(200#mu#g/只)选择性损毁脑内去甲肾腺能(NE)系统可促进达乌尔黄鼠 冬眠, 其损毁范围涉及下丘脑、大脑皮层、海马、中脑导水管等处。用小剂量6-OH DA (4#mu#g/#mu#l)分别双侧注射下丘脑内侧视前区(MPA)、外侧视前区(LPA)、下丘脑的腹内侧核(VMH)。结果表明: 损毁MPA的NE支配可促进黄鼠冬眠; 说明MPA是接受NE系统影响并参与冬眠调制的主要部位; 损毁LPA。对冬眠无影响; 损毁VMH区NE支配结果与损毁MPA区相近, 但其 主要作用机制有待进一步的研究。图1表1参17

关键词： 冬眠; 下丘脑; 去甲肾腺能神经; 黄鼠

Modulation of norepinephrinergic control of hypothalamus preoptic areas on hibernation bouts in ground squirrels (Citellus dauricus)

Fang Xiaohong, Cai Yipeng

Department of Biology, Peking University. Beijing 100871

Abstract

In our previous work, it was shown that hibernaition could be enhanced by injection of 6--hydroxydopamine (6--OHDA, 200#mu#g) into the lateral cerebral ventricle of ground squirrels by destructing norepinephrine (NE) nerve terminals in brain areas including hypothalamus, cerebral cortex, hippocampus and periaqueductal gray matter of middle brain. In order to identify the specific area contributing for the modulation of NE system on hibernation, small doses of 6--OHDA (4#mu#g) were microinjected bilaterally into medial preoptic hypothalamus (MPA), lateral preoptic hypothalamus (LPA) and ventromedial hypothalamic nucleus (VMH). The results showed; (1) Deplection of NE on MPA may facilitate hibernation. (2)Little effect was seen by microinjection of 6--OHDA into LPA. (3)The effect of 6--OHDA on VMH was similar to that on MPA, through the mechanism remains to be investigated

Key words: Hibernation;Hypothalamus;Norepinephrine;Ground squirrel

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引用本文：

方晓红, 蔡益鹏. 黄鼠下丘脑视前区NE能神经支配对冬眠阵的调制[J]. 生理学报 1995; 47 (2): .

Fang Xiaohong, Cai Yipeng. Modulation of norepinephrinergic control of hypothalamus preoptic areas on hibernation bouts in ground squirrels (Citellus dauricus). Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).