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脑室注射NE对室旁核神经内分泌大细胞的作用

纪亚平, 梅俊, 唐斌

西安医科大学脑和神经研究室. 陕西, 西安 710062

摘要

在成年SD大鼠上, 用玻璃微电极进行细胞外记录, 结合逆行鉴定技术确定下丘脑室旁核神经内分泌大细胞, 并观察其对去甲肾上腺素的反应。在49个逆行鉴定神经元中, 位相型、快连续型及慢不规则型放电单位分别占42.9%、36.7%及20.4%。脑室内注射去甲肾上腺素(0.2#mu#g/ml)对位相型单位主要产生抑制作用, 对快连续及慢不规则单位主要为兴奋作用。脑室内注射酚妥拉明(2#mu#g/ml)能部分拮抗NE对位相型神经元的抑制。结果表明: NE对室旁核中 不同类型放电单位作用不同, 其对位相型单位抑制作用可能由#alpha#受体参与介导。图5参18

关键词： 下丘脑; 室旁核; 神经内分泌; 逆行鉴定; 去甲肾上腺素; 酚妥拉明

Effects of intracerebroventricular administration of norepinephrine on paraventricular neurosecretory cells

Ji Yaping, Mei Jun, Tang Bin

Deartment of Brain and Nerve, Xi^an Medical University. Xi^an 710061, Shaanxi

Abstract

Extracellular electrical activities of paraventricular nucleus (PVN) cells were recorded in anaesthetized adult rats by using glass microelectrodes. After antidromical identification of the magnocellular neurosecretory cells, the effects of intracere broventricular (i. c. v.) injection of norepinephrine (NE) on such cells were observed. Of 49 neurons of antidromic stimulation, phasic, fast continuous and slowly irregularly firing units constituted 42.9%, 36.7%, and 20.4% of the total population respectively. With i.c.v. injection, NE inhibited the activity of most phasically firing units, but enhanced that of most fast continuous and slowly irregular firing units. The inhibition effect of NE could be partially antagonized by i.c.v. injection of phentolamine (2#mu#g/#mu#l), showing that the effect is possibly mediated by #alpha#--receptor. The above findings indicate that NE plays different roles in different PVN magnocellular neurons having different patterns of firing activity.

Key words: Hypothalamus;Paraventricular nucleus;Neurosecretory;Antidromical identification;Norepinephrine phentolamine;

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引用本文：

纪亚平, 梅俊, 唐斌. 脑室注射NE对室旁核神经内分泌大细胞的作用[J]. 生理学报 1995; 47 (2): .

Ji Yaping, Mei Jun, Tang Bin. Effects of intracerebroventricular administration of norepinephrine on paraventricular neurosecretory cells. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).